北京大學定量生物學中心

學術報告 

題    目: Effects of gene transfer in phage-host coevolution

報告人: Dr. Wenping Cui

Kavli Institute for Theoretical Physics, UC Santa Barbara

時    間: 4月6日（周四）13:00-14:00

地    點: 呂志和樓B101報告廳

主持人: 林傑 研究員

摘 要:

Bacterial hosts and phages have been in an ongoing arms race for billions of years, leading to the evolution of various antiphage defense and corresponding counter-defense systems. Recent studies have revealed the arsenal for defense and counter-defense systems is much more diverse than previously expected. Individuals can only carry a small portion of all systems due to the constrained genome size of phages and potential fitness burdens on hosts. However, both hosts and phages frequently lose and gain defense and counter-defense systems through gene transfer.

The role of the rapid turnover of these systems in host-phage coevolution is still poorly understood. We develop stochastic Lotka-Volterra models incorporating gene transfer processes to investigate this problem. The system exhibits distinct dynamical behaviors at different gene transfer rates. Our analytical result shows low gene transfer rates are sufficient to maintain genetic diversity above stochastic fluctuations, demonstrating their importance in stable coexistence of diverse phages and hosts.

報告人簡介：

崔文平博士，2011年畢業于中國科學技術大學天文系獲得本科學位，2014年在德國波恩大學取得碩士學位，2021年在美國波士頓學院獲得物理博士學位，現于美國加州大學聖芭芭拉分校卡維裡理論物理研究所擔任博士後研究員，研究方向為生物物理，主要應用自旋玻璃、随機矩陣理論、以及非平衡态等統計物理方法，研究複雜生态系統及群體遺傳學。