北京大學定量生物學中心

學術報告

題    目: 新方法發現人類在93萬年前幾乎滅絕

報告人: 李海鵬 研究員

中科院上海營養健康所

時    間: 10月9日（周一）13:00-14:00

地    點: 呂志和樓B101

主持人: 韓敬東 教授

摘 要:

Population size history is essential for studying human evolution. However, ancient population size history during the Pleistocene is notoriously difficult to unravel. In this study, we developed a fast infinitesimal time coalescent process (FitCoal) to circumvent this difficulty and calculated the composite likelihood for present day human genomic sequences of 3,154 individuals. Results showed that human ancestors went through a severe population bottleneck with about 1,280 breeding individuals between around 930,000 and 813,000 years ago. The bottleneck lasted for about 117,000 years and brought human ancestors close to extinction. This bottleneck is congruent with a substantial chronological gap in the available African fossil record. Our results provide new insights into our ancestry and suggest a coincident speciation event.

參考文獻：

Hu, Wangjie, et al. "Genomic inference of a severe human bottleneck during the Early to Middle Pleistocene transition." Science 381.6661 (2023): 979-984.

報告人簡介：

李海鵬為中科院上海營養健康所研究員，緻力于發展進化生物學新理論和計算生物學新方法，從數學和計算的視角解析與基礎研究、社會生活相關的重要生物學問題，發表SCI論文70餘篇。為中國營養學會營養與組學技術分會副主任委員、中國生物信息學會（籌）系統生物學專委會常委、Front Genet副主編及多個期刊編委。主要學術貢獻為：創建采用全基因組數據估計群體進化曆史後再檢測正選擇的校準型經典方法體系；創建從非平衡溯祖樹檢測正選擇的理論體系；發現瀕危脊椎動物群體數量在一個世紀内下降了約95%；發展正選擇檢測新方法，精準定位PAS1增強子，揭示PAS1-Lhx2對社會階層形成的關鍵作用；将人工智能引入群體遺傳學；建制化開發國産多組學綜合分析軟件eGPS；開發新冠病毒基因組浏覽器；創立快速極小時間溯祖新理論，發現93萬年前人類祖先幾乎滅絕。