北京大學定量生物學中心

學術報告 

題    目: Mechano-morphogenesis and Self-organization in Bacterial Biofilms

報告人: 張秋婷 博士

副教授，北京航空航天大學機械工程及自動化學院

時    間: 3月18日（周一）13:00-14:00

地    點: 呂志和樓B101

主持人: 林傑 研究員

摘 要:

Biofilms are surface-associated bacterial communities embedded in an extracellular matrix. Bacterial biofilms can cause chronic infections and they clog pipes and filters in industry. In many conditions, biofilms grow inside a structured, confined environment. However, despite the importance of the bacteria-environment interaction, little is known as to how mechanical confinement interferes with the biofilm developmental program and how the proliferation of biofilm cells, in turn, deforms or even damages the surrounding environments as feedback to control the biofilm growth. In this presentation, using Vibrio cholerae as a model biofilm former, we reveal the biophysical and biomechanical principles underlying biofilm formation, from a soft matter perspective. We present technique to image living, growing bacterial biofilms from single founder cells to ten thousand cells at single-cell resolution. Moving to more medically relevant environments, we investigate the mechanical feedback between biofilm growth and environmental deformation, at both the continuum level and single-cell level.

報告人簡介：

張秋婷，北京航空航天大學機械工程及自動化學院副教授，博士生導師，國家級青年人才。2019年博士畢業于美國天普大學，後于2019-2022年在美國耶魯大學從事博士後研究員工作。主要研究方向包括生物活性軟物質物理與力學、多功能微納仿生表面的結構設計與制造、智能超材料、軟體機器人等。在PNAS、Nat. Phys.、JMPS、Nat. Commun.、Adv. Funct. Mater.等期刊發表SCI論文20餘篇。