教育經曆:

2002 – 2006 本科，beat365官方网站，獲理學學士學位
2006 – 2011 碩博連讀研究生, beat365官方网站，獲理學博士學位

工作經曆:

2011 – 2013 博士後，美國克利夫蘭醫學中心Lerner研究所，細胞與分子醫學系
2013 – 2019 博士後，beat365官方网站
2019 至今 副研究員，beat365官方网站

榮譽獎勵:

北京大學教學優秀獎，2024
北京大學第二十三屆青年教師教學基本功比賽（理工科類）一等獎，2024
beat365官方网站東寶獎教金，2024

雜志任職:

2023 至今 《Journal of Genetics and Genomics》青年編委

執教課程:

本科生 遺傳學讨論 春季學期
本科生 發育生物學 春季學期
本科生 發育生物學實驗 春季學期

研究生CLS項目 發育生物學基礎 秋季學期

      信号轉導是發育的基礎，貫串生命進程始終。在個體發育中，細胞感知并解析外界和内源發育信号，通過信号轉導将其轉化為對核内基因的表達調控，從而改變細胞理化狀态，協同周圍細胞完成發育中的關鍵細胞學進程。這些發育信号，既包括經典的形态發生素等，也有短肽/氨基酸、糖、脂等代謝産物。信号轉導異常精密和準确，信号的産生、識别和解讀過程中任何細節的微小誤差或失衡都可能會造成發育異常或代謝紊亂。我們圍繞“發育信号的調控機制”這一前沿科學問題，以果蠅和小鼠為研究模型，結合果蠅與哺乳動物細胞培養體系，綜合經典遺傳篩選分析方法、細胞生化手段和先進成像技術，從多角度和多層次探讨發育信号的調控機理，為發育和脂代謝相關疾病的治療提供理論基礎。

Gao Y.*, Feng J.*, Zhang Y., Yi M., Zhang L., Yan Y., Zhu A.J.# and Liu M.# (2024) Ehbp1 orchestrates orderly sorting of Wnt/Wingless to the basolateral and apical cell membranes. EMBO Rep. 25(12): doi: 10.1038/s44319-024-00289-1.

Wang Y., Zhou J., Yang Q., Li X., Oiu Y., Zhang Y.#, Liu M.# and Zhu A.J.# (2024) Therapeutic siRNA targeting PLIN2 ameliorates steatosis, inflammation, and fibrosis in steatotic liver disease models. J.Lipid Res. 65: 100635.

He T.*, Fan Y.*, Du J., Yi M., Li Y., Liu M.#, Zhu A.J.# (2023) Stuxnet fine-tunes Notch dose during development using a functional Polycomb response element. Development 150: dev201297.

Zhao W.*, Zhang Y.*#, Lin S., Li Y., Zhu A.J., Shi H.#, Liu M.# (2023) Identification of Ubr1 as an amino acid sensor of steatosis in liver and muscle. J. Cachexia Sarcopenia Muscle 14: 1454-1467.

Zhang Y.*, Lin S.*, Peng J.*, Liang X., Yang Q., Bai X., Li Y., Li J., Dong W., Wang Y., Huang Y., Pei Y., Guo J., Zhao W., Zhang Z., Liu M.#, Zhu A.J.# (2022) Amelioration of hepatic steatosis by dietary essential amino acid-induced ubiquitination. Mol. Cell 82: 1528-1542.

He T.*, Fan Y.*, Wang Y., Liu M.#, Zhu A.J.# (2022) Dissection of the microRNA network regulating Hedgehog signaling in Drosophila. Front. Cell Dev. Biol. 10: 866491.

Liu M.*, Su Y.*, Peng J., Zhu A.J. (2021) Protein modifications in Hedgehog signaling. BioEssays 43: e2100153.

Gan T.*, Fan L.*, Zhao L., Misra M., Liu M., Zhang M.#, Su Y.# (2021) JNK signaling in Drosophila aging and longevity. Int. J. Mol. Sci. 22: 9649.

Zhang Y.*, Teng D.*, Lu W. *, Liu M.*, Zeng H., Cao L., Southcott L., Potdar S., Westerman E., Zhu A.J.#, Zhang W.# (2021) A widely diverged locus involved in locomotor adaptation in Heliconius butterflies. Sci. Adv. 7: eabh2340.

Liu M.*, Liu A.*, Wang J.*, Zhang Y., Li Y., Su Y.#, Zhu A.J.# (2021) Competition between two phosphatases fine-tunes Hedgehog signaling. J. Cell Biol. 220: e202010078.

Liu M.*, Li Y.*, Liu A., Li R., Su Y., Du J., Li C., Zhu A.J.# (2016) The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development. eLife 5: e17200.

Du J.*, Zhang J.*, He T., Li Y., Su Y., Tie F., Liu M., Harte P.J., Zhu A.J.# (2016) Stuxnet facilitates the degradation of polycomb protein during development. Dev. Cell 37: 507-519.

Zhang J., Du J., Lei C., Liu M., Zhu A.J.# (2014) Ubpy controls the stability of the ESCRT-0 subunit Hrs in development. Development 141: 1473-1479.

Gao G.*, Vibranovski M. D.*, Zhang L., Li Z., Liu M., Zhang Y. E., Li X., Zhang W., Fan Q., VanKuren N. W., Long M.#, Wei L.# (2014) A long-term demasculinization of X-linked intergenic noncoding RNAs in Drosophila melanogaster. Genome Res. 24: 629-638.

Zhang J.*, Liu M.*, Su Y., Du J., Zhu A.J.# (2012) A targeted in vivo RNAi screen reveals deubiquitinases as new regulators of Notch signaling. G3 (Bethesda) 2: 1563-1575.

Du J., Zhang J., Su Y., Liu M., Ospina J.K., Yang S., Zhu A.J.# (2011) in vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling. PLoS One 6: e24168.

Liu M.*, Liu P.*, Zhang L., Gao G., Zhang W., Zhu Z., Liu D.#, Fan Q.# (2011) mir-35 is involved in intestine cell G1/S transition and germ cell proliferation in C. elegans. Cell Res. 21: 1605-1618.

Wang X.*, Liu M.*, Li W., Suh CD., Zhu Z., Jin Y., Fan Q.# (2009) The function of a spindle checkpoint gene bub-1 in C. elegans development. PLoS One 4: e5912.

Li Z.*, Liu M.*, Zhang L.*, Zhang W., Gao G., Zhu Z., Wei L., Fan Q.#, Long M.# (2009) Detection of intergenic non-coding RNAs expressed in the main developmental stages in Drosophila melanogaster. Nucleic Acids Res. 37: 4308-4314.

實驗室成員：
董 巍、劉 敏、馮婧
博士後：張樂冰、張延松（博雅博士後)、範 昱 (博雅博士後)、林思遠 (博雅博士後)
研究生：黃 穎 (SLS)、王 潔 (SLS)、亓 淼 (PTN)、楊 琪 (SLS)、李錦華 (SLS)、王 堯 (SLS)、徐 滢 (SLS)、楊 迪 (SLS)、孟心瀚 (PTN)、蘇 桐 (SLS)、李常清 (SLS)、程啟翔（PTN)、李逸之 (4+4)
客座學生：李佳義
本科生：蔣馨歐，戰陽陽、姚嘉一、鄒瀚琳、周佳欣、潘彥哲、顧欣怡、張惠雯
實驗室電話(010)-6276-1444