教育經曆:

1992，博士學位，微生物學系，愛爾蘭國立大學科克學院；
1984，學士學位，分子生物學專業，中國科學技術大學生物系；

工作經曆:

1999.7-至今，教授，beat365官方网站
1994.8-1999.6，副教授，beat365官方网站
1993，博士後，法國巴斯德研究所分子生物學部
1991-1992，Research Scientist，愛爾蘭Bio-Research Ireland Food Biotechnology Center
1986，訪問學者，德國比勒費爾德大學遺傳學系
1984-1985，實習研究員，中科院植物研究所固氮研究室

社會服務工作:

2020-2024，國家重點研發計劃《合成生物學專項》“高效生物固氮回路的設計與系統優化”項目首席科學家
2010–2014，國家“973”重大基礎研究計劃生物固氮項目首席科學家
2004，第十四屆國際固氮大會主席
2002–2006，國家“973”重大基礎研究計劃生物固氮項目首席科學家
1995.10-2002.8，beat365官方网站副院長

榮譽獎勵:

1999年國家傑出青年基金獲得者

雜志任職:

2021-2014, Editorial Board Member with Current Opinion in Microbiology 2015-now, Editorial Board Member with Research in Microbiology

      本實驗室主要興趣在于：　　　　
　　多年來，本實驗室的工作得到國際同行的認可。主要得到國家自然科學基金、國家科技部“863”、“973”項目基金、國家教育部基金資助、中法先進合作項目、Human Frontier Science Program等項目資助。主要工作包括：大腸杆菌及相關細菌中的基因調控網絡，尤其是碳代謝和氮代謝的調控偶聯；大腸杆菌及相關細菌中的基因調控機理；植物與微生物相互作用的分子生物學及功能基因組學研究；生物修複領域的研究（功能基因的分離）；合成生物學及生物固氮；大腸杆菌定量生物學研究等。取得的主要成就有，發現原核基因表達調控中碳代謝及氮代謝之間的新的偶聯作用及其分子機理；發現DNA物理特性參與基因表達調控（該成果被國際知名學術網站Faculty of 1000 推薦）；提出了激活蛋白－啟動子DNA－σ54-RNA聚合酶所形成的激活複合體的“三明治”結構模型（該成果被國際知名學術網站Faculty of 1000 推薦；使用合成生物學方法，我們使用T7 RNA聚合酶表達系統替代原有的σ54 RNA聚合酶對固氮基因簇的轉錄調控，繞開了原有固氮基因簇對轉錄調控系統中14種調控蛋白的依賴，為最終實現固氮基因向真核系統的轉移打下堅實的基礎；以肺炎克氏杆菌钼鐵固氮基因簇為底盤，成功的在大腸杆菌中構建了雜合的鐵鐵固氮酶體系，從而在不損失酶活的前提下，成功構建了雜合的隻含有10個結構基因的最小鐵鐵固氮酶體系（Yang et al. 2014，PNAS）；證明來源于植物葉綠體和根部白體的電子傳遞鍊模塊能夠功能替代钼鐵及鐵鐵固氮酶系統中負責電子傳遞的原始模塊，提供底物還原所需的還原力的工作（Yang and Xie et al. 2017, PNAS。該論文被PNAS期刊推薦為“From the cover”封面文章）；以及将極其複雜的需要十幾個甚至幾十個基因協同表達的钼鐵固氮酶系統簡化為五個編碼Polyprotein的巨型基因，并證明其高活性可支持大腸杆菌以氮氣作為唯一氮源生長的工作（Yang and Xie et al. 2018, PNAS。該論文被PNAS期刊推薦為“From the cover”封面文章），以上研究具有裡程碑式的意義,為最終實現固氮基因向真核系統的轉移打下堅實的基礎。

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